Hydrochloric Acid → HCID 178508313, compound
Reaction equation
C[Si](C)(C)CCOC[N:7]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[NH:21][N:20]=[N:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)=[N:8]1.Cl>CO>[NH:7]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[NH:21][N:20]=[N:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)=[N:8]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 7-(1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrazol-3-yl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (120 mg, 0.361 mmol) in MeOH (2 mL) was treated with HCl (4-M in dioxan, 1 mL), stirred for 2 h, filtered and the resulting solid washed with Et2O to give the title compound (76 mg, 100%) as a yellow solid.
Workup
- filtrationfiltered
- washthe resulting solid washed with Et2O
Sources & evidence
- ORD record
- ord-de282914200d40ba956dd0054fc4274b
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589097B2
Reaction notes
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