Isoamyl Nitrite → HCID 53419315, compound
Reaction equation
N[C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[N:3]=1.C(ON=O)CC(C)C>C1COCC1>[CH2:10]([O:9][C:7]([C:6]1[CH:2]=[N:3][N:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[CH:5]=1)=[O:8])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of the ester from Step 1 (0.5 g, 1.61 mmol) in THF (4.3 mL) was added isoamylnitrite (0.434 mL, 3.23 mmol), and the mixture was refluxed for 16 hours. It was cooled to room temperature, concentrated, dried and used as such for the subsequent step without any purification.
Workup
- temperaturethe mixture was refluxed for 16 hours
- concentrationconcentrated
- customdried
- customwithout any purification
Sources & evidence
- ORD record
- ord-37887dfd4d7249bfaa4acf1cd72e031b
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589116B2
Reaction notes
Loading…