BROMINE CHLORIDE (BrCl) → 2-(4-Bromothiophen-2-ylethynyl)-5-(4-chlorophenyl)pyridine

HRID 734844

Reaction equation

HRID 734844 reaction equation
Br[C:2]1[S:3][CH:4]=[C:5]([Br:7])[CH:6]=1.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[CH:22])=[N:19][CH:20]=2)=[CH:11][CH:10]=1.BrCl>>[Br:7][C:5]1[CH:6]=[C:2]([C:22]#[C:21][C:18]2[CH:17]=[CH:16][C:15]([C:12]3[CH:13]=[CH:14][C:9]([Cl:8])=[CH:10][CH:11]=3)=[CH:20][N:19]=2)[S:3][CH:4]=1

Participants

4

Reactant 3

HCID 61697BROMINE CHLORIDE (BrCl)2×HCID 2724560Thiophene, 2,4-dibromo-HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 690554352-(4-Bromothiophen-2-ylethynyl)-5-(4-chlorophenyl)pyridine

Procedure

The product was obtained analogously to Example 7.1e starting from 2,4-dibromothiophene and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 0.78 g (50% of theoretical); C17H9BrClNS (M=374.683); calc.: molpeak (M+H)+: 374/376/378 (BrCl); found: molpeak (M+H)+: 374/376/378 (BrCl); HPLC-MS: 7.40 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom7.40 minutes (method B)

Sources & evidence

ORD record
ord-2a6c6e1e5fbe45b59a49c621ac3ab274
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Linked notes

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