2-Amino-5-bromopyrazine → HCID 22249088, compound

HRID 734883

Reaction equation

HRID 734883 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1OB(O)O>CCOC(C)=O>[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 5995392-Amino-5-bromopyrazineHCID 219844772,4-Dichlorophenylboric acid

Product 1

HCID 22249088HCID 22249088, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The product was prepared analogously to Example 48.1a from 1.74 g (10.0 mmol) of 5-bromopyrazin-2-ylamine and 1.91 g (10.0 mmol) of 2,4-dichlorophenylboric acid. Yield: 800 mg (33% of theoretical); C10H7Cl2N3 (M=240.088); calc.: molpeak (M+H)+240/242/244 (2 Cl); found: molpeak (M+H)+:240/242/244 (2 Cl); Rf value: 0.35 (silica gel, PE/EtOAc 7:3).

Sources & evidence

ORD record
ord-41eca724a3374b0c8058ee92855dd827
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Linked notes

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