Hydrogen Peroxide → HCID 11976494, compound

Reaction equation

[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]#[N:11].[OH-:14].[Na+].OO>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]([NH2:11])=[O:14]

Participants

Reactant 3

HCID 784Hydrogen Peroxide

HCID 14798Sodium Hydroxide

HCID 11976442HCID 11976442, compound

Product 1

HCID 11976494HCID 11976494, compound

Procedure

Hydrolysis of 2-(2,3-difluorophenyl)-2-methylpropionitrile was performed according to the procedure of Example 10 using sodium hydroxide in the presence of hydrogen peroxide to provide 2-(2,3-difluorophenyl)isobutyramide [1H-NMR (CDCl3): δ 7.17-7.08 (m, 3H), 5.98 (br s, 1H), 5.45 (br s, 1H), 1.60 (s, 6H)].

Sources & evidence

ORD record: ord-437635596d0544c1814bc456fb85e614
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595338B2

Reaction notes

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