Acetic Acid → 5-Bromo-2-(tetrahydropyran-4-yl)aminoaniline

A 3-neck flask was charged with 5-bromo-2-(tetrahydropyran-4-yl)nitrobenzene (see Working Example 18-1) (3.54 g, 11.8 mmol) and 10% aqueous acetic acid solution (65 mL), after which electrolytic iron (6.56 g, 118 mmol) was added and this was refluxed with stirring for 15 minutes. After this was allowed to cool to room temperature, the insoluble material was filtered off through Celite, and this same layer was further washed with 10% aqueous acetic acid solution (65 mL). The filtrate and the wash solutions were combined and then successively extracted with ethyl acetate (approx. 50 mL, 4 times), washed with distilled water (30 mL), and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and further drying under reduced pressure yielded the title compound (2.72 g, 85.4% yield) as a pale yellow solid.

1. temperaturethis was refluxed
2. filtrationthe insoluble material was filtered off through Celite
3. washthis same layer was further washed with 10% aqueous acetic acid solution (65 mL)
4. extractionsuccessively extracted with ethyl acetate (approx. 50 mL, 4 times)
5. washwashed with distilled water (30 mL)
6. dry with materialdried over anhydrous sodium sulfate
7. distillationThe solvent was distilled off under reduced pressure
8. customfurther drying under reduced pressure

ORD record

ord-6d53bc48aa9b474c99fc67ba238410a5

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08829035B2