1-Iodopropane → 2-Propenoic acid, 3-(3-methoxy-4-propoxyphenyl)-, ethyl ester

HRID 743048

Reaction equation

[OH:1][C:2]1[CH:14]=[CH:13][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][C:3]=1[O:15][CH3:16].[CH2:17](I)[CH2:18][CH3:19]>>[CH3:16][O:15][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:2]=1[O:1][CH2:17][CH2:18][CH3:19])/[CH:6]=[CH:7]/[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 736681Ethyl Ferulate

Product 1

HCID 64507182-Propenoic acid, 3-(3-methoxy-4-propoxyphenyl)-, ethyl esterYield 91.4%

Procedure

Following a procedure similar to that described in Preparation 116, but using 11.11 g of ethyl (E)-4-hydroxy-3-methoxycinnamate and 10.20 g of propyl iodide, 12.08 g of the title compound were obtained.

Workup

customthat described in Preparation 116

Sources & evidence

ORD record: ord-6c351286ee1f47fa877b64f9c11dda70
Source dataset: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05556852

Linked notes

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