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Methanol → HCID 178484913, compound

HRID 745259
Notes
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Reaction equation

HRID 745259 reaction equation
Cl.C1(=O)[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]3[CH:25]=[CH:24][C:19]([C:20](=[NH:23])OC)=[CH:18][CH:17]=3)=[CH:10][CH:9]=2)[C:5](=[O:26])[C:4]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:3]12.C(Cl)(Cl)[Cl:33].[CH3:36][OH:37].[CH3:38][NH2:39]>CCOCC>[ClH:33].[CH3:38][NH:39][C:20](=[NH:23])[C:19]1[CH:18]=[CH:17][C:16]([CH:15]=[CH:14][C:11]2[CH:12]=[CH:13][C:8]([CH2:7][N:6]3[C:36](=[O:37])[C:27]4=[CH:28][CH:29]=[CH:30][CH:3]=[C:4]4[C:5]3=[O:26])=[CH:9][CH:10]=2)=[CH:25][CH:24]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 887MethanolHCID 6212ChloroformHCID 6329MethylamineHCID 70474423HCID 70474423, compound

Product 1

HCID 178484913HCID 178484913, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 1 g of methyl 4-[2-(4-phthalimidomethylphenyl)ethenyl]benzimidate hydrochloride, were added 60 ml of chloroform and 0.2 ml of a methanol solution containing 40% of methylamine. The mixture was stirred at room temperature for 15 hours and stripped of the solvent under reduced pressure. Ether was added to the residue and the precipitated crystals were collected by filtration to yield 0.33 g of N-methyl-4-[2-(4-phthalimidomethylphenyl)ethenyl]benzamidine hydrochloride; m.p. ≥280° C.

Workup

  1. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-c47374660332453bad13723e44d6339c
Source dataset
uspto-grants-1986_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04598077

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes