Water → 1-Amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

HRID 746179

Reaction equation

HRID 746179 reaction equation
C([NH:8][C:9]1([C:12]([CH:14]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][C:15]2([CH3:22])[CH3:21])=[CH2:13])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.O.[OH-].[K+]>FC(F)(F)C(O)=O>[NH2:8][C:9]1([C:12]([CH:14]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][C:15]2([CH3:22])[CH3:21])=[CH2:13])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 70445455N-Boc-1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

Product 1

HCID 201644421-Amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-Boc-1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane is dissolved in trifluoroacetic acid and the solution is stirred overnight. Water is added and the mixture is made basic with 20% KOH. The mixture is extracted with ether, and the organic layer is dried over Na2SO4 and is evaporated to yield 1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane.

Workup

  1. extractionThe mixture is extracted with ether
  2. dry with materialthe organic layer is dried over Na2SO4
  3. customis evaporated

Sources & evidence

ORD record
ord-fa1ab37073b8466690f34c54835671c3
Source dataset
uspto-grants-1986_07
Patent number
US04603012

Linked notes

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