HCID 17788760, compound → 3-(3-Cyanophenoxy)propanoic acid
Reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][CH2:8][C:9]([O:11]C)=[O:10])#[N:2]>Cl>[C:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])#[N:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
500 mg (2.4 mmol) of methyl 3-(3-cyanophenoxy)propionate was heated in 40 ml of 6 N hydrochloric acid at 70° C. for 30 minutes. After the extraction with ethyl acetate, the extract was washed with saturated aqueous NaCl solution and then dried on anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.
Workup
- extractionAfter the extraction with ethyl acetate
- washthe extract was washed with saturated aqueous NaCl solution
- dry with materialdried on anhydrous magnesium sulfate
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-a0f90bcfe61f4b89968b8c87665793a1
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07396844B1
Reaction notes
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