Pyridinium chloride → 7-Acetyl-4-hydroxybenzo[d]thiazol-2(3H)-one
Reaction equation
[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([O:14]C)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Cl.N1C=CC=CC=1>CN1CCCC1=O.O>[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([OH:14])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]Participants
5
Procedure
A mixture of 7-acetyl4-methoxy-1,3-benzothiazol-2(3H)-one (1.2 g), pyridine hydrochloride (2.77 g), in dry 1-methyl-2-pyrrolidone(6 ml), was heated at 190° C. in a microwave reactor for 90 min. The reaction mixture was cooled to room temperature, and diluted with water. The precipitated solid was collected by filtration, washed with water and dried under vacuum at 40° C. to give the title compound (1.07 g). LCMS RT=2.46 min.
Workup
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
- customdried under vacuum at 40° C.
Sources & evidence
- ORD record
- ord-fe87213bfd7e406bb29aebc33ee06b8e
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07402598B2
Reaction notes
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