Ammonium Hydroxide → 2-Amino-1-methylcyclohexan-1-ol
Reaction equation
[CH3:1][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3]2.[OH-].[NH4+:10]>O>[NH2:10][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1([CH3:1])[OH:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.
Workup
- extractionextracted with EtOAc
- dry with materialThe organic phases were dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-0e1f6b80027642ee843f29d90f473c6d
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829007B2
Reaction notes
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