Cesium carbonate → 2-Benzyl-2-(2,2,2-trifluoroethyl)malononitrile

HRID 749517

Reaction equation

HRID 749517 reaction equation
[CH2:1]([CH:8]([C:11]#[N:12])[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].FC(F)(F)S(O[CH2:25][C:26]([F:29])([F:28])[F:27])(=O)=O>CN(C)C=O>[CH2:1]([C:8]([CH2:25][C:26]([F:29])([F:28])[F:27])([C:9]#[N:10])[C:11]#[N:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 158462-(Phenylmethyl)propanedinitrileHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

Product 1

HCID 222350112-Benzyl-2-(2,2,2-trifluoroethyl)malononitrileYield 55.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.1 g of benzylmalononitrile, 5 ml of N,N-dimethylformamide, 0.073 g of cesium carbonate, and 0.1 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate, and according to the process described in the Production Example 1, there was obtained 0.057 g of 2-benzyl-2-(2,2,2-trifluoroethyl)malononitrile (the present compound (3)).

Sources & evidence

ORD record
ord-6c709c2162a5461d965f19b5ab0a6509
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Linked notes

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