Cesium carbonate → 2-(2,2,3,3,3-Pentafluoropropyl)-2-(4-(trifluoromethyl)benzyl)malononitrile

HRID 749584

Reaction equation

HRID 749584 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[Cs+].[Cs+].FC(F)(F)S(O[CH2:29][C:30]([F:36])([F:35])[C:31]([F:34])([F:33])[F:32])(=O)=O>CN(C)C=O>[F:35][C:30]([F:36])([C:31]([F:34])([F:33])[F:32])[CH2:29][C:8]([CH2:7][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:15])([F:16])[F:1])=[CH:14][CH:13]=1)([C:11]#[N:12])[C:9]#[N:10]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 27760192,2,3,3,3-Pentafluoropropyl trifluoromethanesulfonateHCID 10656743(4-(Trifluoromethyl)benzyl)malononitrile

Product 1

HCID 222350672-(2,2,3,3,3-Pentafluoropropyl)-2-(4-(trifluoromethyl)benzyl)malononitrileYield 34%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.50 g of (4-(trifluoromethyl)benzyl)malononitrile, 5 ml of N,N-dimethylformamide, 363 mg of cesium carbonate, and 0.63 g of 2,2,3,3,3-pentafluoropropyl trifluoromethanesulfonate, and according to the process described in the Production Example 1, there was obtained 0.20 g of 2-(2,2,3,3,3-pentafluoropropyl)-2-(4-(trifluoromethyl)benzyl)malononitrile (the present compound (76)).

Sources & evidence

ORD record
ord-d98cfaa7544d4cb78377b0370f214263
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Linked notes

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