Tetramethyl cyclobutane-1,2,3,4-tetracarboxylatato(2-) → 1,2,3,4-Cyclobutanetetracarboxylic Acid

HRID 749625

Reaction equation

HRID 749625 reaction equation
[CH:1]1([C:17]([O:19]C)=[O:18])[CH:4]([C:5]([O:7]C)=[O:6])[CH:3]([C:9]([O:11]C)=[O:10])[CH:2]1[C:13]([O:15]C)=[O:14]>Cl>[CH:2]1([C:13]([OH:15])=[O:14])[CH:1]([C:17]([OH:19])=[O:18])[CH:4]([C:5]([OH:7])=[O:6])[CH:3]1[C:9]([OH:11])=[O:10]

Participants

3

Reactant 1

HCID 266035Tetramethyl cyclobutane-1,2,3,4-tetracarboxylatato(2-)

Product 1

HCID 2660341,2,3,4-Cyclobutanetetracarboxylic AcidYield 88.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The resultant tetramethyl cyclobutane-1,2,3,4-tetracarboxylate (1224 g, 4.25 mol) and aqueous hydrochloric acid (3000 ml) were added to a 5-liter flask; reacted at a controlled temperature of 85° C. for 24 hours; cooled to room temperature; concentrated; and dried to obtain cyclobutane-1,2,3,4-tetracarboxylic acid (870 g, 3.75 mol).

Workup

  1. customreacted at a controlled temperature of 85° C. for 24 hours
  2. concentrationconcentrated
  3. customand dried

Sources & evidence

ORD record
ord-fc15c68955324ce5a28bd88a6b93d097
Source dataset
uspto-grants-2008_07
Patent number
US07402693B2

Linked notes

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