2-Butyloxirane → 4-[(2-hydroxyhexylamino)methyl]benzenesulfonamide Hydrochloride

HRID 750334

Reaction equation

[ClH:1].[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1.[O:14]1[CH:16]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:15]1>>[ClH:1].[OH:14][CH:16]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:15][NH:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH2:13])(=[O:11])=[O:12])=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 150362-Butyloxirane

HCID 67313Mafenide Hydrochloride

Product 1

HCID 691562954-[(2-hydroxyhexylamino)methyl]benzenesulfonamide Hydrochloride

Procedure

In the same manner as in Example 452, Step 1, the title compound was synthesized from 4-aminomethylbenzenesulfonamide hydrochloride and 1,2-epoxyhexane.

Sources & evidence

ORD record: ord-5e8cd8e0f500425c904816ebe30daad2
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07402595B2

Linked notes

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