Water → 6-chloro-1H-pyrazolo[3,4-d]pyrimidine
Reaction equation
[NH2:1][NH2:2].[Cl:3][C:4]1[N:9]=[C:8](Cl)[C:7]([CH:11]=O)=[CH:6][N:5]=1.O>C1COCC1>[Cl:3][C:4]1[N:9]=[C:8]2[NH:1][N:2]=[CH:11][C:7]2=[CH:6][N:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of hydrazine (Aldrich, 64 mg, 2 mmol) in THF (5 mL), 2,4-Dichloro-pyrimidine-5-carbaldehyde (Example 17, 176 mg, 1 mmol) was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. 128 mg, 82%. MS (M+H)+, 155.
Workup
- extractionextracted with EtOAc
- dry with materialThe extract was dried with sodium sulfate
- customthe solvent was removed
- customto give an orange solid
Sources & evidence
- ORD record
- ord-d7915d3b22ff4823aa12afe4cc5ad059
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07405220B2
Reaction notes
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