Lithium Hydroxide → 4-Pentynoic acid, 5-[4-(trifluoromethoxy)phenyl]-

Reaction equation

C[O:2][C:3](=[O:19])[CH2:4][CH2:5][C:6]#[C:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=1.[Li+].[OH-]>>[F:16][C:15]([F:17])([F:18])[O:14][C:11]1[CH:10]=[CH:9][C:8]([C:7]#[C:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 688211875-(4-Trifluoromethoxy-phenyl)-pent-4-ynoic acid methyl ester

Product 1

HCID 688226854-Pentynoic acid, 5-[4-(trifluoromethoxy)phenyl]-

Procedure

In analogy to the procedure described for example 1 e], 5-(4-trifluoromethoxy-phenyl)-pent-4-ynoic acid methyl ester was treated with LiOH to obtain the title compound as brown crystals.

Sources & evidence

ORD record: ord-4c565c9b52aa4e8aae6880b86b50d312
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405236B2

Reaction notes

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