2-Bromopyridine → 2-(2-Amino-5-bromobenzoyl)pyridine
Reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[C:11](O)=[O:12]>>[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[C:11]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:12]Participants
3
Procedure
The anion of 2-bromo-pyridine 121 and 2-amino-5-bromobenzoic acid 122 were condensed to provide the 2′-pyridylketone 123.
Workup
- customcondensed
Sources & evidence
- ORD record
- ord-d272ddba4e234dcbb567bbba99bc673c
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08835424B2
Reaction notes
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