Acetaldehyde → HCID 178419014, compound

HRID 7530

Reaction equation

HRID 7530 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:8]1([N+:14]#[C-:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH:16](=[O:18])[CH3:17].[C:19]([Cl:22])(=O)[CH3:20]>Cl(O)(=O)(=O)=O>[Cl-:22].[C:16]([N+:1]1[C:19]([CH3:20])=[C:15]([NH:14][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]=12)(=[O:18])[CH3:17]

Participants

6

Reactant 4

HCID 177AcetaldehydeHCID 6367Acetyl chlorideHCID 79782-AminopyrimidineHCID 79129Cyclohexyl isocyanide

Product 1

HCID 178419014HCID 178419014, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 24 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-d0df49b2497040b5aed415ee76af723d
Source dataset
uspto-grants-2006_08
Patent number
US07087607B2

Linked notes

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