N-(1-(4-Iodophenyl)propan-2-YL)acetamide → 4-Iodo-alpha-methylbenzeneethanamine

HRID 76163Notes

Reaction equation

HRID 76163 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11]C(=O)C)[CH3:10])=[CH:4][CH:3]=1>Cl>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([NH2:11])[CH3:10])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 66611344N-(1-(4-Iodophenyl)propan-2-YL)acetamide

Product 1

HCID 1238704-Iodo-alpha-methylbenzeneethanamine

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

9.00 g (29.69 mmol) N-[2-(4-iodo-phenyl)-1-methyl-ethyl]-acetamide (I52.1) are added to 150 mL HCl (4N) and the reaction mixture is stirred at reflux over night. Then the mixture is diluted with soda lye and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

Workup

  1. temperatureat reflux over night
  2. additionThen the mixture is diluted with soda lye
  3. extractionextracted with EtOAc
  4. dry with materialThe organic layer is dried with Na2SO4
  5. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-6972a19953ff4a0ca677f361275db46a
Source dataset
uspto-grants-2014_09
Patent number
US08835472B2

Reaction notes

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