Hydrochloric Acid → 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride

HRID 76172

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([NH:21]C(=O)OC(C)(C)C)[CH3:20])=[CH:14][CH:13]=2)=[CH:6][CH:5]=1)[CH3:2].[ClH:29]>CO>[ClH:29].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]([NH2:21])[CH3:20])=[CH:16][CH:17]=2)=[CH:6][CH:5]=1)[CH3:2]

Participants

Conditions

Temperature: 70 °C

Procedure

To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.

Workup

customThe solvent is removed in vacuo
customthe crude product is triturated with DIPE
customdried in normal atmosphere

Sources & evidence

ORD record: ord-9977905a0b844ee4aae5f5837004ce90
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08835472B2

Linked notes

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