HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(1-(4-((4-Chlorophenyl)ethynyl)phenyl)propan-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzene, 1-chloro-4-ethynyl- | HCID 70118 | — |
| Reactant | N-(1-(4-Iodophenyl)propan-2-YL)acetamide | HCID 66611344 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Sec-Butylamine | HCID 24874 | — |
| Product | N-(1-(4-((4-Chlorophenyl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 56924958 | — |
Reaction Steps
To 45.5 mg (0.15 mmol) N-(1-(4-iodophenyl)propan-2-yl)acetamide (I52.1) and 27.3 mg (0.20 mmol) 1-chloro-4-ethynylbenzene in 750 μl sec-butylamine are added 14.3 (0.02 mmol) bis(triphenyphosphine)dichloropalladium (in 400 μl sec-butylamine) followed by 1.0 mL water. The reaction mixture is stirred at r.t. overnight. The solvent is removed in vacuo and the residue is purified by HPLC (ACN/H2O/TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835472B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7ab3636260214442aeb49d5e398ff055 |
| Source note | uspto-grants-2014_09 |