2-Piperidone → 1-(3-Benzylsulfanyl-5-fluoro-2-methoxy-phenyl)piperidin-2-one

HRID 76808

Reaction equation

HRID 76808 reaction equation
[CH2:1]([S:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11](Br)[C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C:20]1=[O:25]>>[CH2:1]([S:8][C:9]1[C:10]([O:17][CH3:18])=[C:11]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C:20]2=[O:25])[CH:12]=[C:13]([F:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 669111041-Benzylsulfanyl-3-bromo-5-fluoro-2-methoxy-benzene

Product 1

HCID 669111631-(3-Benzylsulfanyl-5-fluoro-2-methoxy-phenyl)piperidin-2-one

Procedure

Intermediate 13 (4.22 g, 12.9 mmol) was treated with piperidin-2-one (1.41 g, 14.2 mmol) according to the procedure described in 1.5). Yield after triturating (with n-heptane-ethyl acetate, 4:1) and filtration: 2.67 g (60%), crystalline solid.

Workup

  1. customYield
  2. customafter triturating
  3. filtration(with n-heptane-ethyl acetate, 4:1) and filtration

Sources & evidence

ORD record
ord-790c40b0a273400db8ed971e83e57c32
Source dataset
uspto-grants-2014_09
Patent number
US08835653B2

Linked notes

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