HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidone → 1-(3-Benzylsulfanyl-5-fluoro-2-methoxy-phenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidone | HCID 12665 | — |
| Reactant | 1-Benzylsulfanyl-3-bromo-5-fluoro-2-methoxy-benzene | HCID 66911104 | — |
| Product | 1-(3-Benzylsulfanyl-5-fluoro-2-methoxy-phenyl)piperidin-2-one | HCID 66911163 | — |
Reaction Steps
Intermediate 13 (4.22 g, 12.9 mmol) was treated with piperidin-2-one (1.41 g, 14.2 mmol) according to the procedure described in 1.5). Yield after triturating (with n-heptane-ethyl acetate, 4:1) and filtration: 2.67 g (60%), crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835653B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-790c40b0a273400db8ed971e83e57c32 |
| Source note | uspto-grants-2014_09 |