2-Oxazolidinone → 4-[2-(2-Oxo-1,3-oxazolidin-3-yl)-1,3-thiazol-4-yl]benzonitrile

Temperature

150 °C

4-(2-bromothiazol-4-yl)benzonitrile (100 mg, 0.38 mmol), 2-Oxazolidinone (49.3 mg, 0.57 mmol), diacetoxypalladium (5.93 mg, 0.03 mmol), cesium carbonate (369 mg, 1.13 mmol), water (10 µl) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (21.82 mg, 0.04 mmol) were suspended in dioxane (2 mL), thoroughly degassed and sealed into a microwave tube and stirred at RT for 20 mins. The reaction was then heated to 150 °C for 10 minutes in the microwave reactor and cooled to RT. Load of rubbish... ABANDONED

ORD record

ord-b8e52e6f1bc8459e8364a7285d41ce7c

Source dataset

750 AstraZeneca ELN dataset

Original link

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