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Citric Acid → Escitalopram

HRID 77255
Notes
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Reaction equation

HRID 77255 reaction equation
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O.[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:76]=[CH:77][C:78]([F:81])=[CH:79][CH:80]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60].C(O)(C(O)=O)=O>O.OCC(CO)O>[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:80]=[CH:79][C:78]([F:81])=[CH:77][CH:76]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 311Citric AcidHCID 5988SucroseHCID 134601AspartameHCID 146571Escitalopram Oxalate

Product 1

HCID 146570Escitalopram

Reagents, catalysts & solvents 2

HCID 753GlycerolSolvent
HCID 962WaterSolvent

Procedure

The composition of the formulation and the amounts of the ingredients are shown in the table below. Citric acid was dissolved in 200 ml of distilled water and then sodium alginate (Protanal LF10/60, FMC Biopolymer), glycerol and sucrose were added and dissolved at 60° C. The obtained solution was cooled to ambient temperature and, then, Aspartame, Escitalopram Oxalate and Fantasy flavor were added and dissolved therein. The resulting solution was cast onto casting mold having casting area of 1,150 cm2 and dried according to Example 3.

Workup

  1. dissolutiondissolved at 60° C
  2. dissolutiondissolved
  3. customdried

Sources & evidence

ORD record
ord-e1b8f4cebdf942f3a50951d8c18284b7
Source dataset
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08840935B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes