Potassium Carbonate → 1-(2-Chloro-5-thiazolylmethyl)piperidine 4-one

HRID 77342

Reaction equation

HRID 77342 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.C([O-])([O-])=[O:10].[K+].[K+].[Cl:15][C:16]1[S:17][C:18]([CH2:21]Cl)=[CH:19][N:20]=1>C(#N)C>[Cl:15][C:16]1[S:17][C:18]([CH2:21][N:2]2[CH2:7][CH2:6][C:5](=[O:10])[CH2:4][CH2:3]2)=[CH:19][N:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27631792-Chloro-5-chloromethylthiazoleHCID 20088740Piperidin-2-one--hydrogen chloride (1/1)

Product 1

HCID 706558451-(2-Chloro-5-thiazolylmethyl)piperidine 4-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

25 gm of piperidone hydrochloride was taken in 250 ml acetonitrile. 68.7 gm of K2CO3 was added under stirring at 60° C., followed by addition of 27.8 gm of 2-chloro-5-chloromethylthiazole and refluxed for 6 hours.

Workup

  1. temperaturerefluxed for 6 hours

Sources & evidence

ORD record
ord-0e71ca6a87394df3ad9714f21e115bdd
Source dataset
uspto-grants-2014_09
Patent number
US08841296B2

Linked notes

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