Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 7812

Reaction equation

HRID 7812 reaction equation
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

Participants

3

Reactant 2

HCID 14923Ammonium Hydroxide2×HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

Product 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

Procedure

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

Workup

  1. temperatureheating

Sources & evidence

ORD record
ord-6c3f3afcea9a427b9b1ed5038ccd9a33
Source dataset
uspto-grants-2006_08
Patent number
US07087623B2

Linked notes

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