Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

HRID 78488

Reaction equation

HRID 78488 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]

Participants

5

Reactant 2

HCID 7841Allyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Product 1

HCID 686235423-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent was evaporated
  4. customto afford crude product that

Sources & evidence

ORD record
ord-b550bf94e1dc44afbb8ef0c33f28bdba
Source dataset
uspto-grants-2014_09
Patent number
US08841334B2

Linked notes

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