Iodine → 5-tert-butyl-3-(2-morpholinoethyl)thiazol-2(3H)-imine

HRID 78531

Reaction equation

[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH:4]=O.[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[S-:17][C:18]#[N:19].[K+].II>>[C:2]([C:3]1[S:17][C:18](=[NH:19])[N:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][O:8][CH2:9][CH2:10]2)[CH:4]=1)([CH3:7])([CH3:6])[CH3:1]

Participants

Reactant 4

HCID 807Iodine

HCID 763353,3-Dimethylbutanal

HCID 4082852-Morpholinoethylamine

HCID 516872Potassium thiocyanate

Product 1

HCID 668521395-tert-butyl-3-(2-morpholinoethyl)thiazol-2(3H)-imine

Procedure

Commercially available 3,3-dimethylbutanal (Aldrich), 2-morpholinoethanamine (Aldrich), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 315A to afford the title compound. MS (ESI+) m/z 270 (M+H)+.

Sources & evidence

ORD record: ord-20bf1fd02fb3407f909fd7192f51f7fa
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08841334B2

Linked notes

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