Methane → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate
Reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].C.[CH2:14]([OH:16])[CH3:15]>>[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:16][CH2:14][CH3:15])=[O:6])[CH3:2]Participants
4
Conditions
- Temperature
- 45 °C
Procedure
Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Methane sulphoic acid (0.1 ml) was added to it. The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.2 g).