Sodium sulfate decahydrate → (6-Methoxypyridin-2-yl)methanol
Reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9](OC)=[O:10])[CH:6]=[CH:5][CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>CCOCC>[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][OH:10])[CH:6]=[CH:5][CH:4]=1Participants
5
Procedure
To methyl 6-methoxypicolinate (4.65 g, 27.8 mmol) in Et2O (100 mL) was added LAH (1.06 g). The reaction mixture was stirred for 4 hours. Celite (10 g) was added, followed by sodium sulfate-decahydrate (5 g). The reaction mixture was filtered and concentrated to provide the desired product (3.36 g).
Workup
- additionCelite (10 g) was added
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-b27c41fc331140c3b665b704143aa163
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08841455B2
Reaction notes
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