Methanol → (+/-)-5-[1-(4'-Tert-butyl-2,6-dimethyl-biphenyl-4-yloxy)-ethyl]-thiophene-2-carboxylic acid ethyl ester

HRID 801632

Reaction equation

HRID 801632 reaction equation
[C:14]([CH3:15])([CH3:16])([CH3:17])[c:18]1[cH:19][cH:20][c:21](-[c:24]2[c:25]([CH3:32])[cH:26][c:27]([OH:31])[cH:28][c:29]2[CH3:30])[cH:22][cH:23]1.[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([CH:11]([CH3:12])[OH:13])[cH:9][cH:10]1.[CH3:70][c:71]1[cH:72][cH:73][cH:74][cH:75][cH:76]1.[CH3:77][OH:78].[N:52]([C:53]([N:54]1[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]1)=[O:60])=[N:61][C:62]([N:63]1[CH2:64][CH2:65][CH2:66][CH2:67][CH2:68]1)=[O:69].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([CH:11]([CH3:12])[O:13][c:27]2[cH:26][c:25]([CH3:32])[c:24](-[c:21]3[cH:20][cH:19][c:18]([C:14]([CH3:15])([CH3:16])[CH3:17])[cH:23][cH:22]3)[c:29]([CH3:30])[cH:28]2)[cH:9][cH:10]1

Participants

7

Reactant 6

HCID 887MethanolHCID 1140TolueneHCID 11776TriphenylphosphineHCID 730421,1'-(Azodicarbonyl)dipiperidineHCID 533020184'-Tert-butyl-2,6-dimethylbiphenyl-4-OLHCID 59355961Ethyl 5-(1-hydroxyethyl)thiophene-2-carboxylate

Product 1

HCID 67484337(+/-)-5-[1-(4'-Tert-butyl-2,6-dimethyl-biphenyl-4-yloxy)-ethyl]-thiophene-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-2e961f336c5b43899899b96b568c9b52
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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