Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-nitropyridine
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>C(O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:12][NH2:13])=[N:3][CH:4]=1)([O-:10])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-chloro-5-nitropyridine (30 mmol, 5.0 g) in absolute ethanol was added a solution of hydrazine hydrate (320 mmol, 15.8 g) in ethanol using syringe pump. At the end of the addition, the reaction was refrigerated. The named product precipitated from the reaction medium, was collected by filtration, and recrystallized from ethanol.
Workup
- additionAt the end of the addition
- customThe named product precipitated from the reaction medium
- filtrationwas collected by filtration
- customrecrystallized from ethanol
Sources & evidence
- ORD record
- ord-6fe2fc3ae60d43a599678970974d3fca
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07087634B2
Reaction notes
Loading…