Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-nitropyridine

HRID 8056

Reaction equation

HRID 8056 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>C(O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:12][NH2:13])=[N:3][CH:4]=1)([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 783082-Chloro-5-nitropyridine

Product 1

HCID 40319312-Hydrazinyl-5-nitropyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 2-chloro-5-nitropyridine (30 mmol, 5.0 g) in absolute ethanol was added a solution of hydrazine hydrate (320 mmol, 15.8 g) in ethanol using syringe pump. At the end of the addition, the reaction was refrigerated. The named product precipitated from the reaction medium, was collected by filtration, and recrystallized from ethanol.

Workup

  1. additionAt the end of the addition
  2. customThe named product precipitated from the reaction medium
  3. filtrationwas collected by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-6fe2fc3ae60d43a599678970974d3fca
Source dataset
uspto-grants-2006_08
Patent number
US07087634B2

Linked notes

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