4-Chloro-2-nitrobenzoic acid → Tert-butyl 2-(benzyloxy)-4-chlorobenzoate

HRID 80574

Reaction equation

HRID 80574 reaction equation
ClC1C=[CH:9][C:5]([C:6](O)=O)=[C:4]([N+]([O-])=O)C=1.[CH2:14]([O:21][C:22]1[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:23]=1[C:24]([OH:26])=[O:25])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]1[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:23]=1[C:24]([O:26][C:5]([CH3:9])([CH3:6])[CH3:4])=[O:25])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 804754-Chloro-2-nitrobenzoic acidHCID 224521542-(Benzyloxy)-4-chlorobenzoic acid

Product 1

HCID 70815245Tert-butyl 2-(benzyloxy)-4-chlorobenzoate

Procedure

Instead of the starting material, that is, 4-chloro-2-nitrobenzoic acid, of Reference Example 6, 2-(benzyloxy)-4-chlorobenzoic acid was used for a similar procedure as in Reference Example 6 to obtain tert-butyl 2-(benzyloxy)-4-chlorobenzoate (compound S12a).

Sources & evidence

ORD record
ord-c70a28985e2b45fcb6c4a427607c4667
Source dataset
uspto-grants-2014_09
Patent number
US08846660B2

Linked notes

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