Hydrochloric Acid → 4-Methyl-5-(2-(1-methylcyclopropyl)pyridin-4-yl)thiazol-2-amine

Reaction equation

[CH3:1][c:2]1[n:3][c:4]([NH:17][C:18](=[O:19])[CH3:20])[s:5][c:6]1-[c:7]1[cH:8][c:9]([C:13]2([CH3:16])[CH2:14][CH2:15]2)[n:10][cH:11][cH:12]1.[CH3:22][CH2:23][OH:24].[ClH:21]>>[CH3:1][c:2]1[n:3][c:4]([NH2:17])[s:5][c:6]1-[c:7]1[cH:8][c:9]([C:13]2([CH3:16])[CH2:14][CH2:15]2)[n:10][cH:11][cH:12]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 86631917N-{4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}-acetamide

Product 1

HCID 575066604-Methyl-5-(2-(1-methylcyclopropyl)pyridin-4-yl)thiazol-2-amine

Sources & evidence

ORD record: ord-4d073f381ea3481f8393af6d6c8702dd
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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