1-[3-(Dimethylamino)propyl]piperazine → Dimethyl-(3-{4-[6-(4-trifluoromethylphenyl)pyridazin-3-yl]piperazin-1-yl}propyl)amine, dihydrochloride

HRID 80880

Reaction equation

HRID 80880 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[CH3:18][N:19]([CH3:29])[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[ClH:1].[ClH:1].[CH3:29][N:19]([CH3:18])[CH2:20][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][N:26]([C:2]2[N:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 27362341-[3-(Dimethylamino)propyl]piperazineHCID 12449554Pyridazine, 3-chloro-6-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 131730765Dimethyl-(3-{4-[6-(4-trifluoromethylphenyl)pyridazin-3-yl]piperazin-1-yl}propyl)amine, dihydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(4-trifluoromethylphenyl)pyridazine and (3-dimethylaminoprop-1-yl)piperazine.

Sources & evidence

ORD record
ord-bff784a44e7047a5b87411598c00cd60
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Linked notes

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