Diethylaminoethyl chloride → Diethyl-(2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}ethyl)amine

HRID 80908

Reaction equation

HRID 80908 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.[CH2:23]([N:25]([CH2:29][CH3:30])[CH2:26][CH2:27]Cl)[CH3:24]>>[CH2:23]([N:25]([CH2:29][CH3:30])[CH2:26][CH2:27][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:8][CH:7]=3)=[CH:14][N:13]=2)[CH2:16][CH2:17]1)[CH3:24]

Participants

3

Reactant 2

HCID 13364Diethylaminoethyl chlorideHCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

Product 1

HCID 15951454Diethyl-(2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}ethyl)amine

Procedure

The title compound was prepared by a similar procedure to that described in Example 55, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 2-diethylaminoethylchloride.

Sources & evidence

ORD record
ord-b83450abfbed40da8dad997e3283dbb8
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Linked notes

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