4-Hydroxyphenylboronic acid → 4-(6-(4-Isopropylpiperazin-1-yl)-pyridazin-3-yl)-phenol

HRID 80943

Reaction equation

HRID 80943 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1.[OH:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[CH:14]([N:11]1[CH2:12][CH2:13][N:8]([C:5]2[N:4]=[N:3][C:2]([C:21]3[CH:22]=[CH:23][C:18]([OH:17])=[CH:19][CH:20]=3)=[CH:7][CH:6]=2)[CH2:9][CH2:10]1)([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 27343604-Hydroxyphenylboronic acidHCID 208231183-Chloro-6-(4-isopropylpiperazin-1-yl)pyridazine

Product 1

HCID 1360994094-(6-(4-Isopropylpiperazin-1-yl)-pyridazin-3-yl)-phenol

Procedure

4-[6-(4-Isopropyl-piperazin-1-yl)-pyridazin-3-yl]phenol was prepared by the general procedure I similar to that described in Example 71, starting from 3-chloro-6-(4-isopropyl-piperazin-1-yl)-pyridazine and (4-hydroxyphenyl)boronic acid.

Sources & evidence

ORD record
ord-52b49a0c39a244d485951f894639c77f
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Linked notes

Loading…