Dichloromethane → 3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one

Reaction equation

[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][O:8][c:9]2[n:10][cH:11][cH:12][c:13]([CH3:26])[c:14]2-[c:15]2[cH:16][c:17]3[cH:18][n:19][c:20]([NH2:25])[n:21][c:22]3[cH:23][cH:24]2)[cH:27][cH:28]1.[Cl:36][CH2:37][Cl:38].[F:29][C:30]([F:31])([F:32])[C:33]([OH:34])=[O:35]>>[O:8]=[c:9]1[nH:10][cH:11][cH:12][c:13]([CH3:26])[c:14]1-[c:15]1[cH:16][c:17]2[cH:18][n:19][c:20]([NH2:25])[n:21][c:22]2[cH:23][cH:24]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 669999546-(2-(4-Methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Product 1

HCID 669999863-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one

Sources & evidence

ORD record: ord-57bcdb89949c40eaa3a562346beeaa3a
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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