Dichloromethane → 4-O-benzyl 3-O-methyl piperidine-3,4-dicarboxylate

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[CH:11]1[CH:12]([C:24](=[O:25])[O:26][CH3:27])[CH2:13][N:14]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:15][CH2:16]1.[Cl:35][CH2:36][Cl:37].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[CH:11]1[CH:12]([C:24](=[O:25])[O:26][CH3:27])[CH2:13][NH:14][CH2:15][CH2:16]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 218742134-O-benzyl 1-O-tert-butyl 3-O-methyl piperidine-1,3,4-tricarboxylate

Product 1

HCID 218742474-O-benzyl 3-O-methyl piperidine-3,4-dicarboxylate

Sources & evidence

ORD record: ord-8ec91ac779874c9c96478408ebe2ca13
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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