Dimethylformamide → 3-Chloro-5-(2,2-diethoxyethoxy)-2-fluoropyridine

HRID 81646

Reaction equation

HRID 81646 reaction equation
[C:1](=O)([O-])[O-].[Cs+].[Cs+].BrC[CH2:9][CH:10]1O[CH2:13][CH2:12][O:11]1.CN(C)[CH:17]=[O:18].[Cl:20][C:21]1[CH:22]=[C:23]([OH:28])[CH:24]=[N:25][C:26]=1[F:27]>O>[Cl:20][C:21]1[C:26]([F:27])=[N:25][CH:24]=[C:23]([O:28][CH2:9][CH:10]([O:18][CH2:17][CH3:1])[O:11][CH2:12][CH3:13])[CH:22]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 10796Cesium carbonateHCID 877762-(2-Bromoethyl)-1,3-dioxolaneHCID 224515553-Chloro-2-fluoro-5-hydroxypyridine

Product 1

HCID 684276023-Chloro-5-(2,2-diethoxyethoxy)-2-fluoropyridineYield 62%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

Cesium carbonate (2.9 g, 8.9 mmol) and 2-(2-bromoethyl)-1,3-dioxolane (990 mg, 5.0 mmol) were added to an N,N-dimethylformamide suspension (10 ml) of 5-chloro-6-fluoropyridin-3-ol (570 mg, 3.9 mmol), and stirred at 100° C. for 4 hours. The reaction solution was cooled to room temperature, water was added, and extracted with ethyl acetate. The organic layer was washed with water and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=70:30) to obtain 3-chloro-5-(2,2-diethoxyethoxy)-2-fluoropyridine (640 mg, yield: 62%) as a colorless oil.

Workup

  1. temperatureThe reaction solution was cooled to room temperature
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated saline water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=70:30)

Sources & evidence

ORD record
ord-a35d61c75ba94b3e85d6a391a327ae05
Source dataset
uspto-grants-2014_09
Patent number
US08846700B2

Linked notes

Loading…