2,4-Dichloropyrimidine → 2-Chloro-4-(pyrimidin-2-ylthio)pyrimidine

HRID 81707

Reaction equation

HRID 81707 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[SH:7].[Cl:8][C:9]1[N:14]=[C:13](Cl)[CH:12]=[CH:11][N:10]=1>>[Cl:8][C:9]1[N:14]=[C:13]([S:7][C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 178418793HCID 178418793, compound

Product 1

HCID 623442802-Chloro-4-(pyrimidin-2-ylthio)pyrimidineYield 93.4%

Procedure

In a procedure analogous to Example 3, reaction of pyrimidine-2-thiol (415 mg, 3.70 mmol) and 2,4-dichloropyrimidine (500 mg, 3.36 mmol) furnished the product (705 mg, 93%).

Sources & evidence

ORD record
ord-57b1410fba5d4f10bd4827e5dae2d70e
Source dataset
uspto-grants-2014_09
Patent number
US08846704B2

Linked notes

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