Benzenamine, 4-(4-morpholinyl)- → N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)acrylamide

HRID 81711

Reaction equation

HRID 81711 reaction equation
Cl[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:19])[CH:17]=[CH2:18])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[O:20]1[CH2:21][CH2:22][N:23]([C:26]2[CH:27]=[CH:28][C:29]([NH:30][C:2]3[N:7]=[C:6]([S:8][C:9]4[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:19])[CH:17]=[CH2:18])=[CH:11][CH:10]=4)[CH:5]=[CH:4][N:3]=3)=[CH:31][CH:32]=2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 86645568N-(4-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide

Product 1

HCID 59491673N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)acrylamideYield 54%

Procedure

In a procedure analogous to Example 8, reaction of N-(4-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide (540 mg, 1.85 mmol) and 4-morpholinoaniline (400 mg, 2.24 mmol) furnished the product (430 mg, 54%).

Sources & evidence

ORD record
ord-232500e12c594893b0354dfb860fbef7
Source dataset
uspto-grants-2014_09
Patent number
US08846704B2

Linked notes

Loading…