Cyanoacetic acid → N-(3-(4-(phenylthio)pyrimidin-2-ylamino)phenyl)-2-cyanoacetamide
Reaction equation
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=3)[N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22]([CH2:24][C:25](O)=[O:26])#[N:23]>>[C:1]1([S:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[C:17]([NH:21][C:25](=[O:26])[CH2:24][C:22]#[N:23])[CH:18]=[CH:19][CH:20]=3)[N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
3
Procedure
In a procedure analogous to Example 15, reaction of N1-(4-(phenylthio)pyrimidin-2-yl)benzene-1,3-diamine (80 mg, 0.27 mmol) and cyanoacetic acid (46 mg, 0.54 mmol) furnished the product (46 mg, 47%).
Sources & evidence
- ORD record
- ord-ab886262780d4573b96b9dc208bd1ba5
- Source dataset
- uspto-grants-2014_09