Trifluoroacetic acid → 2-Bromo-1-methyl-1H-pyrrole-3-sulfonamide
Reaction equation
[Br:1][C:2]1[N:3]([CH3:15])[CH:4]=[CH:5][C:6]=1[S:7]([NH:10]C(C)(C)C)(=[O:9])=[O:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[N:3]([CH3:15])[CH:4]=[CH:5][C:6]=1[S:7]([NH2:10])(=[O:8])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 7.11 g (24 mmol) of 2-bromo-N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide in 50 mL methylene chloride under a nitrogen atmosphere was added 50 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the crude residue and was removed by evaporation to remove residual TFA, which yielded 1.23 g of the title compound as a light brown solid.
Workup
- concentrationThe reaction mixture was concentrated in vacuo
- additionThree portions of diethyl ether were added to the crude residue
- customwas removed by evaporation
- customto remove residual TFA, which
Sources & evidence
- ORD record
- ord-952e75b6acac43568991fc07fe11133a
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723410
Reaction notes
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