Pyridine → N-[4-Bromo-3-(trifluoromethyl)phenyl]-2-methylpropanamide

Reaction equation

[Br:1][c:2]1[c:3]([C:9]([F:10])([F:11])[F:12])[cH:4][c:5]([NH2:6])[cH:7][cH:8]1.[C:13]([CH:14]([CH3:15])[CH3:16])(=[O:17])[Cl:18].[cH:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>>[Br:1][c:2]1[c:3]([C:9]([F:10])([F:11])[F:12])[cH:4][c:5]([NH:6][C:13]([CH:14]([CH3:15])[CH3:16])=[O:17])[cH:7][cH:8]1

Participants

Reactant 3

HCID 1049Pyridine

HCID 62325Isobutyryl chloride

HCID 678524-Bromo-3-(trifluoromethyl)aniline

Product 1

HCID 21312299N-[4-Bromo-3-(trifluoromethyl)phenyl]-2-methylpropanamide

Sources & evidence

ORD record: ord-832f2d9bda2441919dd8a213f2198ebe
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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