Dichloromethane → 5-(5-(3-Hydroxy-3-methylbut-1-ynyl)-4-(piperidin-4-ylmethylamino)pyridin-2-ylamino)pyrazine-2-carbonitrile

Reaction equation

[C:8](#[N:9])[c:10]1[n:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:38]#[C:39][C:40]([CH3:41])([CH3:42])[OH:43])[c:21]([NH:23][CH2:24][CH:25]3[CH2:26][CH2:27][N:28]([C:31]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:37])[CH2:29][CH2:30]3)[cH:22]2)[n:14][cH:15]1.[Cl:44][CH2:45][Cl:46].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[C:8](#[N:9])[c:10]1[n:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:38]#[C:39][C:40]([CH3:41])([CH3:42])[OH:43])[c:21]([NH:23][CH2:24][CH:25]3[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]3)[cH:22]2)[n:14][cH:15]1