Water → 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

HRID 822277

Reaction equation

[CH:57]([OH:58])([CH3:59])[CH3:60].[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:22]1)[N:7]([CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[CH2:8][C:9]([F:14])([F:15])[C:10](=[O:13])[N:11]2[CH3:12].[NH2:35][c:36]1[c:37]([O:55][CH3:56])[cH:38][c:39]([C:40](=[O:41])[NH:42][CH:43]2[CH2:44][CH2:45][N:46]([CH2:49][CH:50]([F:51])[F:52])[CH2:47][CH2:48]2)[cH:53][cH:54]1.[OH2:23].[c:24]1([CH3:25])[c:26]([S:27]([OH:28])(=[O:29])=[O:30])[cH:31][cH:32][cH:33][cH:34]1>>[c:2]1([NH:35][c:36]2[c:37]([O:55][CH3:56])[cH:38][c:39]([C:40](=[O:41])[NH:42][CH:43]3[CH2:44][CH2:45][N:46]([CH2:49][CH:50]([F:51])[F:52])[CH2:47][CH2:48]3)[cH:53][cH:54]2)[n:3][cH:4][c:5]2[c:6]([n:22]1)[N:7]([CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[CH2:8][C:9]([F:14])([F:15])[C:10](=[O:13])[N:11]2[CH3:12]